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GSH deficiency results in the activation of von Willebrand Factor (Ibrahim et al., 2004) and in the accumulation of ROS, which affect clotting and platelet activation, impair endothelial function, and predispose to the risk of thrombotic events (Violi et al., 2017): notably, hypercoagulation is a prominent life-threatening complication in COVID-19 patients ( Notably, low GSH plasma levels have been identified along with three other clinical indicators (age, CD3 ratio, and total protein) as a predictor of the severe/critical symptoms of COVID-19 infected patients (Sun et al., 2020)

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